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PANS/PANDAS: The Role of Infection and Toxin-Mediated Neuroinflammation in Mental Health Disorders
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In the early 1990s, a group of researchers at the National Institute of Mental Health began collecting data on children who had developed neuropsychiatric disorders (OCD and tics) following infections. They found evidence that antineuronal antibodies had developed in some of these children which attacked the basal ganglia region of the brain. MRI and PET scans in these children also demonstrated inflammatory changes in the basal ganglia. In 1997, the researchers published the first article to describe this syndrome that they named PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep infections).
In PANDAS, an autoimmune attack on the brain occurs following a Strep infection. PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) is a broader term that also includes cases following exposure to other infections, toxins, and even stress. Clinicians treating children with PANS and PANDAS have found that antibiotics targeted at the offending organisms, steroids, and IVIG results in marked improvement and occasionally complete remission of the neuropsychiatric symptoms.
Disturbing symptoms consistent with many DSM-5 psychiatric disorders manifest in patients with PANS and PANDAS—yet we know that there is a biologic basis for the changes in these children. As a result, these disorders require us, as physicians and society, to view mental illness in an entirely new way. Resistance to this change in paradigm has made PANS and PANDAS difficult for clinicians to diagnose, unbearable for parents to endure, and controversial for scholars to accept.
PANS and PANDAS are complex disorders that demand a rich, multifaceted response with novel treatment approaches.
This lecture, by one of the world’s top experts in PANS and PANDAS, will explain the actual link between immune dysregulation in these children and the development of these syndromes. In this presentation, participants will find conclusive evidence from the peer-reviewed medical literature for the existence and pathophysiology of PANS and PANDAS, alongside testing and treatment interventions the author has successfully used in his own practice with hundreds of children.
Scott Antoine, DO, FACEP, ABOIM
Scott Antoine, DO, FACEP, ABOIM, completed his undergraduate training at the University of Scranton, his doctorate at the Philadelphia College of Osteopathic Medicine and his emergency medicine residency and fellowship at Albert Einstein Medical Center in Philadelphia. He served seven years of active duty with the United States Army as an emergency physician, followed by a practice as an emergency physician at St. Francis Hospital in Indianapolis. In addition to his board certification in emergency medicine, he achieved board certification in integrative medicine through the newly formed American Board of Integrative Medicine in 2016. He also holds certifications in functional medicine through the Institute for Functional Medicine and A4M. In 2013, his daughter developed Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). He and his wife Ellen, also a functional and integrative medicine physician, were able to shut off the immune response, treat the infections and toxins responsible for her PANS presentation and bring her to full recovery. After his daughter recovered from PANS, he knew his specialty had found him. Since then, he has refined his process and has helped hundreds of children recover from PANS and PANDAS. In 2019, he successfully lobbied the Indiana legislature and helped pass a law which prohibits insurance companies from denying coverage from medical care (including IVIG) for children with PANS and PANDAS.
Speaker Disclosures:
Financial: Dr. Scott Antoine is the owner of The Center for Fully Functional Health®. He receives a speaking honorarium from Psychotherapy Networker and PESI, Inc. He has no relevant financial relationships with ineligible organizations.
Non-financial: Dr. Scott Antoine is a member of the American Medical Association, the Institute of Functional Medicine. the American Academy of Anti-Aging Medicine, the American Academy of Ozonotherapy, the American College of Emergency Physicians, and the American Board of Emergency Medicine.
