Tania Singer, head of the Social Neuroscience Lab of the Max Planck Society in Berlin, and colleagues have conducted a wide range of studies about mindfulness and self-awareness with a broad aim of finding ways to foster mental health, heartfelt connections and social cooperation. Their work has examined the interpersonal aspects of heart rate variability (HRV), exogenous generation of emotions (EGE), social capacities such as compassion, empathy and Theory of Mind as well as interoceptive body awareness, alexithymia and the effects of socio-affective and cognitive mental training on brain plasticity. The most important project was the ReSource project, a multi-disciplinary 9-month longitudinal mental training study involving more than 300 participants and 90 different measures. The goal was to compare the effects of three different types of 3-month mental training modules on brain plasticity, social connectedness, wellbeing and affect, the immune- and stress-system, interoceptive body awareness, social intelligence and prosocial behaviors. The findings from these studies are highly relevant to interoceptive-, mindfulness- and compassion-based treatments such as the Internal Family Systems therapy (IFS) whose founder Dick Schwartz will discuss the clinical implications of Dr. Singer's work.