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Digital Seminar

Novel and Not So Novel Anticoagulants: Mechanism of Action, Indications for Clinical Use and Therapeutic Monitoring

Paul Langlois, APN, PhD, CCRN, CCNS
2 Hours 06 Minutes
Audio and Video
Mar 24, 2022
Product Code:
Media Type:
Digital Seminar


Options for anticoagulation have been expanding steadily over the past few decades, providing a greater number of agents for prevention and management of thromboembolic disease. In addition to heparins and vitamin K antagonists, anticoagulants that directly target the enzymatic activity of thrombin and factor Xa have been developed. Appropriate use of these agents requires knowledge of their individual characteristics, risks, and benefits.

In this recording, we highlight with clinical case studies and pharmacodynamic data the practical aspects of the use of direct thrombin inhibitors (oral and parenteral) and oral direct factor Xa inhibitors, along with other anticoagulants in development (medications which target the active form of factor XI and monoclonal antibody Blocking factor XI).

Indications and efficacy of anticoagulants in specific clinical settings and under clinical conditions are presented. Moreover, management of bleeding and perioperative management of patients receiving direct thrombin inhibitors and direct factor Xa inhibitors will also be discussed.


* Credit Note - **

NOTE: Tuition includes one free CE Certificate (participant will be able to print the certificate of completion after completing the on-line post-test (80% passing score) and completing the evaluation). 

Continuing Education Information:  Listed below are the continuing education credit(s) currently available for this non-interactive self-study package. Please note, your state licensing board dictates whether self-study is an acceptable form of continuing education, as well as which credit types are acceptable for continuing education hours. Please refer to your state rules and regulations. If your profession is not listed, please contact your licensing board to determine your continuing education requirements and check for reciprocal approval. For other credit inquiries not specified below, please contact or 800-844-8260 before the event.

Materials that are included in this course may include interventions and modalities that are beyond the authorized practice of your profession.  As a licensed professional, you are responsible for reviewing the scope of practice, including activities that are defined in law as beyond the boundaries of practice in accordance with and in compliance with your profession's standards.  

For Planning Committee disclosures, please statement above.  For speaker disclosures, please see the faculty biography.

Nurses - Pharmacology Nurse Practitioners

This self-study program offers 120 instructional minutes of pharmacology content which is designed to qualify for 2.0 contact hours toward your pharmacology requirement. 

Nurses - Nurses, Nurse Practitioners, and Clinical Nurse Specialists - ANCC

PESI, Inc. is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation. Nurses completing these self-study materials will earn 2.0 contact hours. Expires: 03/24/2025.

Nurses - California Nurses

PESI, Inc. is a provider approved by the California Board of  Registered Nursing, Provider #: 17118 for 2.0 self-study contact hours. 

** You will need to provide your license number to PESI. PESI must have this number on file in order for your hours to be valid.

Nurses - Florida Nurses

PESI, Inc. is an approved provider by the Florida Board of  Nursing. Provider #: FBN2858. These materials qualify for 2.0 self-study contact hours.

CE Broker

Nurses - Iowa Nurses

PESI, Inc. is an approved provider by the Iowa Board of Nursing. Provider #: 346. Nurses successfully completing these self-study materials will earn 2.0 self-study contact hours. Please email with your license number, include the title, speaker name and date. PESI must have this number on file in order for your hours to be valid.

Physicians - Physicians

PESI, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. PESI, Inc. designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. This activity was originally recorded on 03/24/2022. It was last reviewed on 03/08/2022 and is valid until 03/08/2025.


Physicians should only claim credit commensurate with the extent of their participation in the activity. You are required to successfully complete and submit a post-test prior to receiving a certificate of completion.

Physicians Assistants - Physician Assistants

AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME such as PESI. Physician assistants may receive a maximum of 2.0 hours for completing this self-study program. This activity was originally recorded on 03/24/2022. It was last reviewed on 03/08/2022 and is valid until 03/08/2025


PESI, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. PESI, Inc. designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™.

Other Professions

This self-study activity qualifies for 2.0 continuing education clock hours as required by many national, state and local licensing boards and professional organizations. Save your activity advertisement and certificate of completion, and contact your own board or organization for specific requirements.



Paul Langlois, APN, PhD, CCRN, CCNS's Profile

Paul Langlois, APN, PhD, CCRN, CCNS Related seminars and products

Paul Langlois, APN, PhD, CCRN, CCNS, is a critical care clinical specialist in the surgical, medical, neurologic, burn, CCU, and trauma ICUs of Cook County Hospital, Chicago. Drawing on over 40 years of experience assessing and managing patients with life-threatening diseases, Dr. Langlois provides advanced-level training to nurses, physician assistants, nurse practitioners, respiratory therapists, and physicians.

Dr. Langlois is committed to providing the highest quality of care to patients through advanced education. His presentations are evidence-based, timely, and provide participants with numerous case studies to facilitate critical thinking. As a bedside clinical nurse specialist, he has developed several institution-wide protocols for the multidisciplinary assessment and management of infectious disease and multi-system organ failure patients.

His presentations are enthusiastically delivered and offer highly practical tips that help make the most challenging concepts easy to understand. Linking knowledge to clinical practice is the goal of every educational program.  


Speaker Disclosures:
Financial: Paul Langlois has employment relationships with Cook County Hospital and Emergency Care Consultants. He receives a speaking honorarium and recording royalties from PESI, Inc. He has no relevant financial relationships with ineligible organizations.
Non-financial: Paul Langlois is a member of the American Nurses Association and the American Association of Critical Care Nurses.

Additional Info

Access for Self-Study (Non-Interactive)

Access never expires for this product.


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  1. Analyze the mechanism of action of vitamin K antagonists.
  2. Distinguish three clinical conditions when anticoagulation is indicated.
  3. Evaluate contraindications when prescribing anticoagulant medications.
  4. Assess therapeutic range for three laboratory tests to monitor anticoagulants.


Unfractionated Heparin
  • Mechanism of action
  • Dosing
  • Laboratory monitoring
  • Reversal agent
Low Molecular Weight Heparin
  • Limited indications for laboratory monitoring
  • Renal Adjustment
Vitamin K Antagonists
  • Mechanism of action on the clotting cascade
  • Monitoring parameters
  • Contraindications for use
  • Reversal agents
Direct Thrombin Inhibitors
  • Mechanism of action
  • Clinical conditions for use
  • Reversal agent
Factor Xa Inhibitors
  • Standard dosing
  • Indications for treating clinical conditions
  • Prophylactic dosing
ADP P2Y12 Receptor Inhibitors
Medications Which Effect Actions of Anticoagulants
  • P-Glycoprotein inhibitors and inducers
  • Cytochrome P-450 inhibitors and inducers
Over the Counter Medications Effecting Coagulation
  • Aspirin
  • Non-steroidal anti-inflammatory drugs
Advantages and Disadvantages of Oral Anticoagulants
Contraindications for Anticoagulation
Case Studies

Target Audience

  • Nurses
  • Nurse Practitioners
  • Physicians
  • Physicians Assistants


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